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1st Australian Workshop on Cell Death

Preliminary Program

 

Sunday August 21st

Arrival/Registration

 

Monday August 22nd

Molecular Pathways in Cell Death

 

7:00 – 9:00               Breakfast

 

8:45 – 10:30    Session I: Death Receptor Signaling

                        Chair: John Silke

 

                                 Janie Borst                A genome-wide screen identifies SRP72 as a key determinant of tumor cell sensitivity to apoptosis-

                                                                     induction by both TRAIL Receptor-1 and -2

                                 Bert vd Kooij            TRAIL-R1 cell surface expression and pro-apoptotic activity is regulated by MARCH-8-mediated

                                                                     ubiquitination

                                 Justine Hill                Understanding how FLIPs inhibit death receptor-mediated apoptosis

                                 Joane O’Donnell      Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak and Bax and inhibited by Bcl-2 and Mcl-1

                                 Donia Moujalled      In the presence of high levels of RIPK3, TNF can cause cell death independent of caspase 8 and RIPK1

                                 Christelle Capini        Modern Imaging Techniques for Cell Death Investigation.   

                                                                                               

10:30– 11:00           Coffee break

 

11:00 – 12:45  Session II: Signaling

                        Chair: Kathy Baran

 

                                 James Rickard              Necroptosis mediated inflammation appears to drive Sharpincpdm/cpdm dermatitis

                                 Najoua Lalaoui            RIP1 kinase activity is required for tumour cell death induced by Smac-mimetics

                                 Jessie Jeffrey               Akt overactivity promotes spindle checkpoint bypass

                                 Yong Shen                   The MUC13 Cell Surface Mucin Protects Against Intestinal Inflammation by Inhibiting Epithelial Cell

                                                                        Apoptosis

                                 Gerry Melino                p53 family, its involvement in neuronal development via miR-43a: Why we need them?

                                 Anissa Jabour              p53-dependent transcriptional responses to Interleukin-3 signaling            

12:45– 13:45            Lunch

 

13:45 – 15:30  Session III: Bcl-2 Family Members   

                        Chair: Christopher Andoniou          

 

                                 Rogier Rooswinkel       Comprehensive profiling of Bcl-2 family members in intact cells

                                 Peter Czabotar               Structures of Bcl-2 family protein complexes provide insights into the regulation of programmed cell death

                                 Dana Wespthal            The deadly shape of Bak and Bax

                                 Colin Hockins               Bax homodimerizes via a BH-3 groove:interface during apoptosis

                                 Stefan Glaser                Role of Bcl-2 family members in acute myeloid leukaemia

                                 Jarrod Sandow              PUMA is phosphorylated at serine 10 to regulate apoptotic activity by signaling PUMA degradation

 

15:30 – 16:00           Coffee break

 

16:00 – 17:45  Session IV: Autophagy and Non-Apoptotic Cell Death

                        Chair: Sharad Kumar            

 

                                 Merril Curry                    The role of plasma membrane calcium ATPase isoforms on caspase-dependent and independent cell death

                                 Nufail Kahn                     cIAP antagonists and IFNγ activate novel caspase and RIPK1 dependent death pathways

                                 Gavin Higgins                 Pathways to the multiplicity of cell death outcomes in oxidatively stressed neurons

                                 Donna Denton                Autophagy and growth arrest are required for drosophila midgut cell death

                                 Kamil Wolyniec              A novel role for E6AP ubiquitin ligase in the development of B-cell lymphoma

                                 Peter Kreuzaler                STAT3 and lysosomes; partners in crime

 

17:45 – 19:30          Dinner

 

19:30 – 21:00  Funding your research. Fellowships, Grants and Companies (instead of poster session)  

                                                          Moderator: Nigel Waterhouse

                                                                             Panel: Ricky Johnstone, Sharad Kumar, John Silke, Gisela Mautner.                          

 

Tuesday August 23rd

Cell Death and Disease

 

7:00 – 9:00               Breakfast

 

9:00 – 10:30    Session V: Immunity and Disease

Chair: Michael Bots     

 

                                 Boris Turk                        Lysosomes and lysosomal proteases as mediators and/or amplifiers of cell death

                                 David Granville               Extracellular granzymes: can too much cleavage be detrimental?

                                 Dawn Cooper                  Granzyme K activates protease-activated receptor 1

                                 Jenny Chia                       Role of perforin in human health and disease 

                                  Margherita Ghisi           Modulation of microRNA (MIR) Expression in human T cell Development: Targeting of Notch 3 by MIR-150

                                 Jane Olario                      TBA

                                 

 

10:30 – 11:00         Coffee break

 

11:00 – 12:30  Session VI: Anti-Apoptotic Signaling

                        Chair: Ruth Kluck      

 

                                 James Vince                      Inhibitor of apoptosis (IAP) proteins regulate IL-1 activity

                                 Melinda Christiensen     The role of anti-apoptotic proteins in the resistance to granule-induced death by cytotoxic lymphocytes

                                 Ueli Nachbur                    XIAP – a double-edged sword for fatal hepatitis

                                 Lynn Wong                      cIAPs and XIAP in combination negatively regulate inflammatory cytokine production and cell death in

                                                                             primary macrophages in a RIPK1/RIPK3 dependent manner

                                 Jacob Qi                             Role of cIAP1 in protecting against ER stress-mediated apoptosis

                                 Pat Fitzgerald                    TBA

 

12:30 – 13:45          Lunch

13:45 – 20:00         Social afternoon

20:00 – 22:00         Dinner

 

Wednesday August 24rd

Cancer and Therapy

7:00 –8:45                Breakfast

 

8:45 – 10:30    Session VII: Bcl-2 Family Members in Health and Disease

                        Chair: Grant Dewson

 

                                 Delphine Mιrino            Killing of lymphoid cells by ABT-737 relies exclusively on its ability to antagonize Bcl-2, not any other

                                                                            family member

                                 Michaela Waibel            Targeting of pro-survival Bcl-2 proteins in haematological malignancies driven by activated mutant JAK2

                                 Livleen Kaur                     Definition of the cellular targets of the parapox virus Bcl-2 like protein orfv125

                                 Kate Lawlor                      Differential effects of a BH3 mimetic on the induction and progression of collagen-induced arthritis

                                 Diane Moujalled              The molecular mechanisms of cAMP-induced apoptosis

                                 Alison Butt                      Dysregulation of apoptotic signaling impacts on the response to tamoxifen in human breast cancer cells

                                                                            and predicts patient outcome and tamoxifen responsiveness in breast cancer

 

10:30 – 11:00           Coffee break

 

 

11:00 – 12:45  Session VIII: Cancer and Chemotherapy I

                        Chair: Dianne Watters 

 

                                 Loretta Dorstyn               Physiological functions of caspase-2: as determined by the analysis of caspase-2 deficient mice and cells

                                 Joey Puccini                     Aberrant DNA damage response and genomic instability in caspase-2 deficient cells

                                 Adrian Wiegmans           Inducing cell death in breast cancer by targeting DNA repair genes

                                 Edwin Hawkins                TBA

                                 Michael Bots                    TBA

                                 Christine Hawkins          Killing cells without inducing mutagenesis or DNA damage

 

12:45 – 14:00            Lunch

 

14:00 – 15:45  Session IX: Chemotherapy and Blood Cancers

Chair: Paul Ekert

 

                                 Adele Baker                    Development of genetically engineered mouse models of the MLL-ENL and MLL-AF9 mutations to study

                                                                           tumorigenesis and identify key molecular targets for the treatment of MLL driven acute leukemia ( AL)

                                 Rebecca Bilardi              BH3 only proteins in MLL-fusion leukemia development and treatment

                                 Gabriela Brumatti           HoxA9 requires Bcl-2 to immortalize myeloid progenitors

                                 Katrina Falkenberg        Identification of novel genes involved in sensitization to histone deacetylase inhibitors

                                 Geoff Matthews             RNAi-mediated loss of HDAC3 partially phenocopies the effects of HDAC inhibitors in Eμ-myc

                                                                           B-cell lymphoma

                                 Lisa Crowley                  Autophagy induction by Bcr-Abl expressing cells can limit efficacy of Imatinib treatment; strategies to

                                                                          improve treatment regimens

 

15:45 – 16:15           Coffee break

 

16:15 - 18:00   Session X: Immunotherapy and Immunogenicity

                        Chair: Christine Hawkins 

 

                                 Helen Beere                     The role of HSP70 in tumorigenesis

                                 Blaine Creasy                  Drak2: A mediator in the survival of autoreactive T cells

                                 Alison West                   Anti-cancer therapy mediated by a histone deacetylase inhibitor engages the immune system

                                 Stephen Mattarollo        Immunogenic cell death elicited by chemotherapy induces innate and adaptive immunity that is critical

                                                                           for anti-cancer therapeutic success

                                 Douglas Green                Fueling immunity: Metabolic reprogramming in activated T lymphocytes

 

18:00 – 18:30         Coffee break

 

18:30 - 19:30   Round table discussion: Is Apoptosis Dead?

                                                                              Moderator: Alison Butt

                                                                              Panel: Doug Green, Gerry Melino, Janie Borst, Boris Turk

 

Thursday August 25th

Departure

7:00 – 11:00            Breakfast

                                 Departure